Tpp2 Gene Summary [Mouse]
Predicted to enable exopeptidase activity; identical protein binding activity; and peptide binding activity. Predicted to be involved in intracellular amino acid homeostasis and protein catabolic process. Predicted to be located in nuclear body. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human TPP2 (tripeptidyl peptidase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Tpp2 |
| Official Name | tripeptidyl peptidase II [Source:MGI Symbol;Acc:MGI:102724] |
| Ensembl ID | ENSMUSG00000041763 |
| Bio databases IDs | |
| Aliases | tripeptidyl peptidase II |
| Synonyms | IMD78, TPP II, tripeptidyl peptidase 2, Tripeptidyl peptidase II |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tpp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tripeptidyl-peptidase
- Peptidase domain in the S8 and S53 families
- tripeptidyl-peptidase II
- peptide binding
- endopeptidase
- Subtilase family
- peptidase
- aminopeptidase
- protein binding
- identical protein binding
- Tripeptidyl peptidase II
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- immunodeficiency 78 with autoimmunity and developmental delay
- Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency
- premature aging
- Evans syndrome
- weight loss
role in cell
- expression in
- proliferation
- quantity
- apoptosis
- cell death
- differentiation
- function
- growth
- length
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tpp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyubiquitination
- proteolysis
- amino acid homeostasis
Cellular Component
Where in the cell the gene product is active
- nuclear body
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- tripeptidyl-peptidase activity
- endopeptidase activity
- serine-type endopeptidase activity
- aminopeptidase activity