Phlda3 Gene Summary [Mouse]
Predicted to enable phosphatidylinositol phosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and positive regulation of apoptotic process. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including extraembryonic component; genitourinary system; hemolymphoid system; intestine; and liver. Orthologous to human PHLDA3 (pleckstrin homology like domain family A member 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Phlda3 |
| Official Name | pleckstrin homology like domain, family A, member 3 [Source:MGI Symbol;Acc:MGI:1351485] |
| Ensembl ID | ENSMUSG00000041801 |
| Bio databases IDs | |
| Aliases | pleckstrin homology like domain, family A, member 3 |
| Synonyms | pleckstrin homology like domain family A member 3, pleckstrin homology-like domain, family A, member 3, TIH1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Phlda3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- phosphatidylinositol-3,4,5-triphosphate binding
- phosphatidylinositol-4,5-bisphosphate binding
- PH domain
- Pleckstrin homology-like domain
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- male pattern hair loss
- keloid
- breast carcinoma
- latent tuberculosis
regulates
- genomic DNA
role in cell
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Phlda3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of apoptotic process
- DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
- anatomical structure morphogenesis
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,4,5-trisphosphate binding
- phosphatidylinositol-4,5-bisphosphate binding
- phosphatidylinositol-5-phosphate binding
- phosphatidylinositol-3,5-bisphosphate binding
- phosphatidylinositol-3-phosphate binding
- phosphatidylinositol-3,4-bisphosphate binding