Hltf Gene Summary [Mouse]
Enables ATP-dependent activity, acting on DNA. Involved in mRNA transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; and regulation of neurogenesis. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; intestine; and sensory organ. Orthologous to human HLTF (helicase like transcription factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hltf |
| Official Name | helicase-like transcription factor [Source:MGI Symbol;Acc:MGI:1196437] |
| Ensembl ID | ENSMUSG00000002428 |
| Bio databases IDs | |
| Aliases | helicase-like transcription factor |
| Synonyms | helicase-like transcription factor, HIP116, HIP116A, HLTF1, P113, RNF80, RUSH, SMARCA3, SNF2L3, ZBU1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hltf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- HIRAN domain
- transcription regulator
- DNA binding domain
- NTP binding domain
- zinc finger of C3HC4-type, RING
- ubiquitin protein ligase activity
- helicase superfamily c-terminal domain
- SNF2-related domain
- nuclear localization sequence
- Ring finger domain
- protein binding
- DNA dependent ATPase
- Helicase conserved C-terminal domain
- DNA binding
- RING-like zinc finger
- helicase domain
- RING-type zinc-finger
- Ring finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- N-terminal helicase domain of the DEAD-box helicase superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Pathways
Biological processes and signaling networks where the Hltf gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- human T-cell lymphotropic virus 1 infection
- hypoglycemia
- prion disease
- spondylarthritis
role in cell
- migration
- activation in
- apoptosis
- quantity
- survival
- proliferation
- function
- formation
- size
- remodeling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hltf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA transcription from RNA polymerase II promoter
- DNA repair
- chromatin remodeling
- positive regulation of transcription from RNA polymerase II promoter
- regulation of neurogenesis
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- nuclear matrix
- nucleolus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- DNA binding
- DNA-dependent ATPase activity
- zinc ion binding
- ubiquitin protein ligase binding
- RNA binding
- protein binding
- hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
- helicase activity