Pdcd7 Gene Summary [Mouse]

Involved in response to glucocorticoid. Acts upstream of or within RNA splicing; positive regulation of T cell apoptotic process; and positive regulation of apoptotic signaling pathway. Part of U2AF complex and spliceosomal complex. Is expressed in several structures, including brain ventricular layer; chondrocranium; jaw; submandibular gland primordium; and vibrissa. Orthologous to human PDCD7 (programmed cell death 7). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Pdcd7
Official Name
programmed cell death 7 [Source:MGI Symbol;Acc:MGI:1859170]
Ensembl ID
ENSMUSG00000041837
Bio databases IDs NCBI: 50996 Ensembl: ENSMUSG00000041837
Aliases programmed cell death 7
Synonyms 59K, ES18, HES18, programmed cell death 7
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pdcd7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Programmed cell death protein 7

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
  • arsenic trioxide
  • imatinib
  • NR3C1
  • plasma cells
  • B lymphocytes
  • T-2 toxin
  • olaparib
  • enzalutamide
regulates
  • DNA promoter
  • RNA polymerase I
  • DNA endogenous promoter

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • spliceosomes
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Pdcd7 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • RNA splicing
  • response to glucocorticoid stimulus
  • apoptotic process

Cellular Component

Where in the cell the gene product is active
  • U12-type spliceosomal complex
  • nucleoplasm

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.