Macc1 Gene Summary [Mouse]
Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Is expressed in epithelium of phallic urethra of male and urethral plate. Orthologous to human MACC1 (MET transcriptional regulator MACC1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Macc1 |
| Official Name | metastasis associated in colon cancer 1 [Source:MGI Symbol;Acc:MGI:2685113] |
| Ensembl ID | ENSMUSG00000041886 |
| Bio databases IDs | |
| Aliases | metastasis associated in colon cancer 1 |
| Synonyms | 4732474O15Rik, 7A5, Gm267, metastasis associated in colon cancer 1, MET transcriptional regulator MACC1, RGD1309838, SH3BP4L |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Macc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Death Domain Superfamily of protein-protein interaction domains
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- metastasis
- pancreatic cancer
- colorectal cancer
- organismal death
regulates
- FN1
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
role in cell
- migration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Macc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell division
- signal transduction
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- growth factor activity