MACC1 Gene Summary [Human]
MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009]
Details
| Type | Protein Coding |
| Official Symbol | MACC1 |
| Official Name | MET transcriptional regulator MACC1 [Source:HGNC Symbol;Acc:HGNC:30215] |
| Ensembl ID | ENSG00000183742 |
| Bio databases IDs | |
| Aliases | MET transcriptional regulator MACC1 |
| Synonyms | 4732474O15Rik, 7A5, Gm267, metastasis associated in colon cancer 1, MET transcriptional regulator MACC1, RGD1309838, SH3BP4L |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MACC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Death Domain Superfamily of protein-protein interaction domains
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- FN1
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- metastasis
- pancreatic cancer
- colorectal cancer
- organismal death
role in cell
- migration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MACC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell division
- signal transduction
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- growth factor activity