Spidr Gene Summary [Mouse]
Predicted to be involved in several processes, including cellular response to camptothecin; cellular response to hydroxyurea; and regulation of double-strand break repair. Predicted to be active in nuclear chromosome and nucleoplasm. Human ortholog(s) of this gene implicated in ovarian dysgenesis 9. Orthologous to human SPIDR (scaffold protein involved in DNA repair). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spidr |
| Official Name | scaffolding protein involved in DNA repair [Source:MGI Symbol;Acc:MGI:1924834] |
| Ensembl ID | ENSMUSG00000041974 |
| Bio databases IDs | |
| Aliases | scaffolding protein involved in DNA repair |
| Synonyms | 2310008H04Rik, KIAA0146, LOC100289549, ODG9, RGD1566036, scaffolding protein involved in DNA repair, scaffold protein involved in DNA repair |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spidr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of unknown function (DUF4502)
- protein binding
- Domain of unknown function (DUF4503)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- familial premature ovarian failure
- ovarian dysgenesis type 9
regulates
- protein-protein complex
role in cell
- growth
- survival
- instability
- response by
- homologous recombination repair in
- sister chromatid exchange in
- homologous recombination in
- DNA damage response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spidr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- double-strand break repair via homologous recombination
- cellular response to ionizing radiation
- cellular response to hydroxyurea
- regulation of double-strand break repair via homologous recombination
- regulation of establishment of protein localization to chromosome
- positive regulation of double-strand break repair
- response to DNA damage stimulus
- positive regulation of protein complex assembly
Cellular Component
Where in the cell the gene product is active
- nuclear chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding