Rmi2 Gene Summary [Mouse]
Predicted to enable DNA binding activity. Predicted to be involved in DNA metabolic process; negative regulation of double-strand break repair via homologous recombination; and regulation of sister chromatid segregation. Predicted to be located in nucleus. Predicted to be part of RecQ family helicase-topoisomerase III complex. Predicted to be active in cytosol and nuclear speck. Is expressed in axial skeleton; bladder; embryo; and rib. Orthologous to human RMI2 (RecQ mediated genome instability 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rmi2 |
| Official Name | RecQ mediated genome instability 2 [Source:MGI Symbol;Acc:MGI:2685383] |
| Ensembl ID | ENSMUSG00000037991 |
| Bio databases IDs | |
| Aliases | RecQ mediated genome instability 2 |
| Synonyms | A630055G03Rik, BLAP18, C16orf75, Gm537, Gm929, MGC24665, RecQ mediated genome instability 2, RGD1563163 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rmi2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- RecQ-mediated genome instability protein 2
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- dementia
- insulin-dependent diabetes mellitus
- organismal death
- multiple sclerosis
- lung adenocarcinoma
- lung adenocarcinoma formation
- leprosy
- inflammatory bowel disease
- systemic lupus erythematosus
role in cell
- expression in
- migration
- mitosis
- invasion by
- segregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rmi2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- regulation of sister chromatid segregation
- negative regulation of double-strand break repair via homologous recombination
- DNA replication
- double-strand break repair via homologous recombination
- resolution of recombination intermediates
- maintenance of rDNA
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- cytosol
- RecQ helicase-Topo III complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding