Grk1 Gene Summary [Mouse]
Predicted to enable rhodopsin kinase activity. Acts upstream of or within several processes, including negative regulation of neuron apoptotic process; photoreceptor cell morphogenesis; and post-embryonic retina morphogenesis in camera-type eye. Located in photoreceptor outer segment. Is expressed in eye and retina outer nuclear layer. Used to study Oguchi disease-2. Human ortholog(s) of this gene implicated in Oguchi disease-2 and night blindness. Orthologous to human GRK1 (G protein-coupled receptor kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Grk1 |
| Official Name | G protein-coupled receptor kinase 1 [Source:MGI Symbol;Acc:MGI:1345146] |
| Ensembl ID | ENSMUSG00000031450 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor kinase 1 |
| Synonyms | GPRK1, G protein-coupled receptor kinase 1, RHOK, RK |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Grk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Regulator of G protein signaling domain
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- rhodopsin kinase
- Regulator of G protein signaling (RGS) domain superfamily
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Grk1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- oguchi disease type 2
- retinal dystrophy
- alopecia areata
- Oguchi disease
- spinocerebellar ataxia type 7
- congenital stationary night blindness
role in cell
- apoptosis
- phosphorylation in
- abnormal morphology
- degeneration
- morphogenesis
- dark adaptation in
- electrophysiology
- inactivation in
- response
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- cytosol
- photoreceptor outer segments
- rod outer segments
- cone outer segments
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Grk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein autophosphorylation
- rhodopsin mediated signaling pathway
- regulation of G-protein coupled receptor protein signaling pathway
- visual perception
- protein phosphorylation
- regulation of signal transduction
- regulation of rhodopsin mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- rhodopsin kinase activity
- protein kinase activity