Gnl3 Gene Summary [Mouse]
Enables GTP binding activity. Predicted to be involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of protein localization to chromosome, telomeric region; and stem cell division. Located in nucleolus and nucleoplasm. Is expressed in several structures, including brain ventricular layer; gut; jaw; liver lobe; and lung. Orthologous to human GNL3 (G protein nucleolar 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Gnl3 |
| Official Name | guanine nucleotide binding protein-like 3 (nucleolar) [Source:MGI Symbol;Acc:MGI:1353651] |
| Ensembl ID | ENSMUSG00000042354 |
| Bio databases IDs | |
| Aliases | guanine nucleotide binding protein-like 3 (nucleolar) |
| Synonyms | C77032, E2IG3, G protein nucleolar 3, guanine nucleotide binding protein nucleolar 3, NNP47, NS, NUCLEOSTEMIN, NUG1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gnl3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- G4 GTP-binding domain
- mRNA 5' UTR binding
- GNL3L/Grn1 putative GTPase
- ribosome biogenesis GTP-binding protein YlqF
- coiled-coil domain
- protein binding
- basic domain
- GTP binding motif, P-loop
- Circularly permuted YlqF-related GTPases
- acidic domain
Pathways
Biological processes and signaling networks where the Gnl3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bipolar disorder
- osteoarthritis
- pancreatic cancer
- glioblastoma
- glioblastoma cancer
regulated by
- lipopolysaccharide
- TP53
- CST5
- guanosine nucleotides
- rebemadlin
- mycophenolic acid
- tretinoin
- dithiothreitol
- actinomycin D
- beta-estradiol
role in cell
- expression in
- apoptosis
- cell death
- disruption in
- proliferation
- degradation in
- differentiation
- G1 phase
- self-renewal
- mitosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- midbody
- chromosome
- prenucleolar bodies
- nucleoplasm
- nucleoli
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gnl3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- stem cell maintenance
- positive regulation of protein sumoylation
- stem cell division
- positive regulation of telomere maintenance
- regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- nuclear body
- membrane
- chromosome
- midbody
- nucleolus
Molecular Function
What the gene product does at the molecular level
- GTP binding
- RNA binding
- protein binding
- mRNA 5'-UTR binding