Orc2 Gene Summary [Mouse]
Enables DNA replication origin binding activity. Predicted to be involved in DNA replication initiation. Located in heterochromatin. Part of inner kinetochore and nuclear origin of replication recognition complex. Is expressed in several structures, including 1st branchial arch maxillary component; brain; genitourinary system; sensory organ; and spleen. Orthologous to human ORC2 (origin recognition complex subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Orc2 |
| Official Name | origin recognition complex, subunit 2 [Source:MGI Symbol;Acc:MGI:1328306] |
| Ensembl ID | ENSMUSG00000026037 |
| Bio databases IDs | |
| Aliases | origin recognition complex, subunit 2 |
| Synonyms | ORC2L, origin recognition complex subunit 2, origin recognition complex, subunit 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Orc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Origin recognition complex subunit 2
- DNA replication origin binding
- protein binding
Pathways
Biological processes and signaling networks where the Orc2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- periodontal pocket
- plexiform neurofibroma
- Huntington disease
role in cell
- transcription in
- apoptosis
- mitosis
- dissociation in
- cell cycle progression
- G1 phase
- dissociation
- S phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- soluble fraction
- chromatin fraction
- nuclear matrix fraction
- heterochromatic focus
- heterochromatin
- telomeric heterochromatin
- Cytoplasm
- centrosome
- nuclear foci
- nucleoplasm
- nucleoli
- nuclear matrix
- kinetochores
- centromeres
- telomeres
- chromatin
- pericentric heterochromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Orc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- DNA-dependent DNA replication initiation
Cellular Component
Where in the cell the gene product is active
- heterochromatin
- nucleus
- chromosome, telomeric region
- origin recognition complex
- condensed chromosome inner kinetochore
- centrosome
- membrane
- nuclear origin of replication recognition complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA replication origin binding
- protein binding