Nle1 Gene Summary [Mouse]
Acts upstream of or within several processes, including chordate embryonic development; hematopoietic stem cell homeostasis; and positive regulation of canonical Wnt signaling pathway. Located in nucleolus. Is expressed in several structures, including 2-cell stage embryo; gonad; hemolymphoid system gland; inner cell mass; and liver. Orthologous to human NLE1 (notchless homolog 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nle1 |
| Official Name | notchless homolog 1 [Source:MGI Symbol;Acc:MGI:2429770] |
| Ensembl ID | ENSMUSG00000020692 |
| Bio databases IDs | |
| Aliases | notchless homolog 1 |
| Synonyms | AL022765, FLJ10458, HUSSY7, l11Jus1, l11Jus4, NLE, NOTCHLESS, notchless homolog 1, RGD1308301, Rsa4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nle1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Anaphase-promoting complex subunit 4 WD40 domain
- NLE (NUC135) domain
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nle1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Notch signaling pathway
- kidney development
- somitogenesis
- ribosomal large subunit biogenesis
- positive regulation of canonical Wnt receptor signaling pathway
- negative regulation of mitotic cell cycle
- inner cell mass cell differentiation
- ribosomal large subunit assembly
- skeletal system morphogenesis
- mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleolus
- nucleoplasm