Nek9 Gene Summary [Mouse]
Predicted to enable protein kinase activator activity; protein kinase binding activity; and protein serine/threonine kinase activity. Predicted to be involved in mitotic cell cycle and regulation of mitotic cell cycle. Predicted to be located in cytoplasm and nucleus. Predicted to colocalize with centrosome. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to human NEK9 (NIMA related kinase 9). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nek9 |
| Official Name | NIMA (never in mitosis gene a)-related expressed kinase 9 [Source:MGI Symbol;Acc:MGI:2387995] |
| Ensembl ID | ENSMUSG00000034290 |
| Bio databases IDs | |
| Aliases | NIMA (never in mitosis gene a)-related expressed kinase 9 |
| Synonyms | APUG, C130021H08Rik, KIAA1995, LCCS10, NC, NERCC, NERCC1, Nercc1 kinase, NIMA (never in mitosis gene a)-related expressed kinase 9, NIMA-related kinase 9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nek9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulator of chromosome condensation (RCC1) repeat
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- kinase
- protein kinase activator
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nevus comedonicus
- hereditary disorder
- arthrogryposis, Perthes disease, and upward gaze palsy
- lethal congenital contracture syndrome type 10
- Hutchinson-Gilford progeria syndrome
- epidermal inclusion cyst
- esophageal adenocarcinoma
- esophageal carcinoma formation
- Goldberg-Shprintzen megacolon syndrome
- productive infection by HIV-1
role in cell
- formation
- G1 phase
- segregation
- S phase
- replication in
- prometaphase
- alignment
- mitosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- centrosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nek9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- mitotic cell cycle
- regulation of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- ATP binding
- protein binding
- metal ion binding
- protein kinase activator activity
- protein serine/threonine kinase activity