MAFF Gene Summary [Human]
The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Details
| Type | Retained Intron |
| Official Symbol | MAFF |
| Official Name | MAF bZIP transcription factor F [Source:HGNC Symbol;Acc:HGNC:6780] |
| Ensembl ID | ENSG00000185022 |
| Bio databases IDs | |
| Aliases | MAF bZIP transcription factor F |
| Synonyms | hMafF, MAF bZIP transcription factor F, MAFF-like, U-MAF, v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAFF often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- Basic region leucine zipper
- protein binding
- sequence-specific DNA binding
- bZIP
- basic region leucin zipper
Pathways
Biological processes and signaling networks where the MAFF gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- metastasis
- breast cancer
- hypoplasia
- non-insulin-dependent diabetes mellitus
- Huntington disease
- chronic periodontal disease
- primary myelofibrosis
role in cell
- expression in
- differentiation
- growth
- induction in
- invasion by
- translocation in
- dysfunction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cellular membrane
- Mitochondria
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAFF gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- skeletal muscle cell differentiation
- in utero embryonic development
- positive regulation of transcription from RNA polymerase II promoter
- regulation of epidermal cell differentiation
- regulation of transcription from RNA polymerase II promoter
- parturition
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity