Bcar3 Gene Summary [Mouse]
Predicted to enable kinase binding activity and phosphotyrosine residue binding activity. Acts upstream of or within lens morphogenesis in camera-type eye and positive regulation of peptidyl-serine phosphorylation. Located in focal adhesion and membrane. Is expressed in brain; retina; submandibular gland primordium; testis; and tongue epithelium. Orthologous to human BCAR3 (BCAR3 adaptor protein, NSP family member). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Bcar3 |
| Official Name | breast cancer anti-estrogen resistance 3 [Source:MGI Symbol;Acc:MGI:1352501] |
| Ensembl ID | ENSMUSG00000028121 |
| Bio databases IDs | |
| Aliases | breast cancer anti-estrogen resistance 3 |
| Synonyms | AND-34, BCAR3 adaptor protein, NSP family member, breast cancer anti-estrogen resistance 3, LOC101928013, MIG7, NSP2, RP11 488P31, SH2D3B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bcar3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase binding
- Src homology 2 (SH2) domain
- phosphotyrosine binding
- protein binding
- RasGEF
- proline rich domain
- guanine nucleotide exchange factor domain
Pathways
Biological processes and signaling networks where the Bcar3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- schizophrenia
- major depression
- adhesions of iris
- multiple system atrophy
- male pattern hair loss
- cataract disease
- open-angle glaucoma
role in cell
- proliferation
- migration
- growth
- formation in
- activation in
- number
- formation
- accumulation in
- morphology
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- perinuclear region
- cellular membrane
- focal adhesions
- membrane ruffles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bcar3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- insulin receptor signaling pathway
- small GTPase mediated signal transduction
- signal transduction
- epidermal growth factor receptor signaling pathway
- positive regulation of cell proliferation
- positive regulation of MAPK cascade
- response to xenobiotic stimulus
- lens morphogenesis in camera-type eye
- positive regulation of GTPase activity
- positive regulation of peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- cytoplasm
- membrane
Molecular Function
What the gene product does at the molecular level
- phosphotyrosine binding
- protein binding
- guanyl-nucleotide exchange factor activity
- kinase binding