Epop Gene Summary [Mouse]
Enables chromatin binding activity. Involved in regulation of transcription by RNA polymerase II; stem cell differentiation; and transcription elongation-coupled chromatin remodeling. Acts upstream of or within neuron fate commitment. Part of ESC/E(Z) complex and elongin complex. Is expressed in brain. Orthologous to human EPOP (elongin BC and polycomb repressive complex 2 associated protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Epop |
| Official Name | elongin BC and polycomb repressive complex 2 associated protein [Source:MGI Symbol;Acc:MGI:2143991] |
| Ensembl ID | ENSMUSG00000043439 |
| Bio databases IDs | |
| Aliases | elongin BC and polycomb repressive complex 2 associated protein |
| Synonyms | C17orf96, E13, E130012A19Rik, elongin BC and polycomb repressive complex 2 associated protein, esPRC2p48, PRR28 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Epop often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- chromatin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Epop gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- stem cell differentiation
- neuron fate commitment
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- ESC/E(Z) complex
- chromosome
- elongin complex
Molecular Function
What the gene product does at the molecular level
- chromatin binding