Dclk1 Gene Summary [Mouse]
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been found, but the biological validity of some variants has not been determined. These variants encode different isoforms, which are differentially expressed and have different kinase activities. [provided by RefSeq, Sep 2010]
Details
| Type | Protein Coding |
| Official Symbol | Dclk1 |
| Official Name | doublecortin-like kinase 1 [Source:MGI Symbol;Acc:MGI:1330861] |
| Ensembl ID | ENSMUSG00000027797 |
| Bio databases IDs | |
| Aliases | doublecortin-like kinase 1 |
| Synonyms | 1700113D08Rik, 2810480F11RIK, AI836758, Ania4, CaMK-related peptide, Carp, CL1, CLICK1, Click-I, CPG16, DCAMKL1, DCDC3A, Dcl, DCLK, doublecortin-like kinase 1, mKIAA0369, RGD:621187 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dclk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- doublecortin domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Doublecortin
- FRY tripeptide sequence
- Protein tyrosine and serine/threonine kinase
- serine/threonine kinase domain
- protein binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Ubl1_cv_Nsp3_N-like
- serine threonine rich domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- acute myeloid leukemia
- Huntington disease
- experimentally-induced diabetes
- hepatitis B
- nonalcoholic fatty liver disease
- lung squamous cell carcinoma
- squamous cell lung cancer
- hemangioma
- angiomatosis
role in cell
- quantity
- proliferation
- apoptosis
- guidance
- migration
- development
- survival
- sphere formation
- formation
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- postsynaptic region
- microtubules
- growth cone
- axons
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dclk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein localization to nucleus
- neuron projection morphogenesis
- nervous system development
- central nervous system projection neuron axonogenesis
- response to virus
- protein phosphorylation
- dendrite morphogenesis
- neuron migration
- forebrain development
- central nervous system development
- axon extension
- endosomal transport
- protein localization to nucleus
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein kinase activity
- protein serine/threonine kinase activity