Naalad2 Gene Summary [Mouse]
Enables N-formylglutamate deformylase activity and carboxypeptidase activity. Involved in carboxylic acid catabolic process. Acts upstream of or within proteolysis. Located in membrane. Orthologous to human NAALAD2 (N-acetylated alpha-linked acidic dipeptidase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Naalad2 |
| Official Name | N-acetylated alpha-linked acidic dipeptidase 2 [Source:MGI Symbol;Acc:MGI:1919810] |
| Ensembl ID | ENSMUSG00000043943 |
| Bio databases IDs | |
| Aliases | N-acetylated alpha-linked acidic dipeptidase 2 |
| Synonyms | 2700022G20Rik, D9Ertd285e, Folh1b, GCP3, GCPIII, GPCIII, NAADALASE2, NAALADASE2, N-acetylated alpha-linked acidic dipeptidase 2, N-acetylated α-linked acidic dipeptidase 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Naalad2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PA domain
- Zinc peptidases M18, M20, M28, and M42
- N-formylglutamate deformylase
- carboxypeptidase
- PA
- peptidase
- Transferrin receptor-like dimerization domain
- protein binding
- Peptidase family M28
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Naalad2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- carboxypeptidase activity
- protein binding
- metallocarboxypeptidase activity
- metal ion binding
- dipeptidase activity
- serine-type peptidase activity
- dipeptidyl-peptidase activity