Celsr2 Gene Summary [Mouse]
Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Involved in several processes, including Wnt signaling pathway; homophilic cell adhesion via plasma membrane adhesion molecules; and neural plate anterior/posterior regionalization. Acts upstream of or within several processes, including cerebrospinal fluid secretion; cilium assembly; and nervous system development. Located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; skin; and visual system. Used to study hydrocephalus. Orthologous to human CELSR2 (cadherin EGF LAG seven-pass G-type receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Celsr2 |
| Official Name | cadherin, EGF LAG seven-pass G-type receptor 2 [Source:MGI Symbol;Acc:MGI:1858235] |
| Ensembl ID | ENSMUSG00000068740 |
| Bio databases IDs | |
| Aliases | cadherin, EGF LAG seven-pass G-type receptor 2 |
| Synonyms | ADGRC2, cadherin EGF LAG seven-pass G-type receptor 2, cadherin, EGF LAG seven-pass G-type receptor 2, CDHF10, EGFL2, flamingo, Flamingo1, Fmi, MEGF3, mfmi1, mKIAA0279 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Celsr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Hormone receptor domain
- 7 transmembrane receptor (Secretin family)
- LamG
- GPCR-Autoproteolysis INducing (GAIN) domain
- Human growth factor-like EGF
- Keratin, high sulfur B2 protein
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- EGF_CA
- Delta serrate ligand
- Laminin-type epidermal growth factor-like domai
- Cadherin repeat-like domain
- EGF domain
- GPCR proteolysis site, GPS, motif
- laminin G domain
Pathways
Biological processes and signaling networks where the Celsr2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- diabetes mellitus
- heart disease
- metabolic disorder
- cardiovascular disorder
- unstable angina
- hypercholesterolemia
- androgenic alopecia
- coronary artery disease
- metabolic syndrome X
regulates
- APOB
- LDL cholesteryl ester
role in cell
- migration
- adhesion
- assembly
- cisplatin sensitivity
- growth
- migration by
- movement
- patterning in
- patterning
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Celsr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- G-protein coupled receptor signaling pathway
- neural plate anterior/posterior regionalization
- regulation of cell-cell adhesion
- regulation of protein localization
- regulation of transcription, DNA-dependent
- homophilic cell adhesion
- cilium movement
- dendrite morphogenesis
- ventricular system development
- Wnt receptor signaling pathway
- Wnt receptor signaling pathway, planar cell polarity pathway
- cerebrospinal fluid secretion
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- calcium ion binding