Ccdc141 Gene Summary [Mouse]
Involved in brain development. Acts upstream of or within centrosome localization and cerebral cortex radially oriented cell migration. Located in centrosome and cytoplasm. Is expressed in several structures, including brain; foregut; reproductive system; respiratory system; and trigeminal nerve. Orthologous to human CCDC141 (coiled-coil domain containing 141). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccdc141 |
| Official Name | coiled-coil domain containing 141 [Source:MGI Symbol;Acc:MGI:1919735] |
| Ensembl ID | ENSMUSG00000044033 |
| Bio databases IDs | |
| Aliases | coiled-coil domain containing 141 |
| Synonyms | 2610301F02Rik, CAMDI, coiled-coil domain containing 141, FLJ39502, GE1568866, LOC100362894, LOC285026 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccdc141 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPEC
- chromosome segregation protein SMC, common bacterial type
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart failure
- atrial ventricular block
- colorectal mucinous adenocarcinoma
- colorectal carcinomagenesis
- early missed abortion
- diabetic nephropathy
- bundle branch block
- hypertrophic cardiomyopathy
- repetitive behavior
- tachycardia
role in cell
- migration
- accumulation in
- localization
- projection
- confusion in
- confusion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- olfactory axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ccdc141 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- centrosome localization
- cerebral cortex radially oriented cell migration
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding