Rrad Gene Summary [Mouse]
Predicted to enable GTP binding activity and calcium channel regulator activity. Predicted to be involved in negative regulation of cell growth. Located in T-tubule. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and musculature. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human RRAD (RRAD, Ras related glycolysis inhibitor and calcium channel regulator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rrad |
| Official Name | Ras-related associated with diabetes [Source:MGI Symbol;Acc:MGI:1930943] |
| Ensembl ID | ENSMUSG00000031880 |
| Bio databases IDs | |
| Aliases | Ras-related associated with diabetes |
| Synonyms | RAD, RAD1, RAS ASSOCIATED with DIABETES, Ras-related associated with diabetes, REM3, RRAD, Ras related glycolysis inhibitor and calcium channel regulator |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rrad often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- small GTP-binding protein domain
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- 50S ribosome-binding GTPase
- Rab subfamily of small GTPases
- GTPase
- enzyme
- protein binding
- Ras of Complex, Roc, domain of DAPkinase
- P-loop containing Nucleoside Triphosphate Hydrolases
- Ras subfamily of RAS small GTPases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- neoplasia
- heart failure
- impaired glucose tolerance
- dermatomyositis
- amyotrophic lateral sclerosis
role in cell
- activation in
- expression in
- growth
- apoptosis
- phosphorylation in
- hypertrophy
- cell cycle progression
- differentiation
- colony formation
- retraction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
- transverse tubules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rrad gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- small GTPase mediated signal transduction
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- calmodulin binding
- protein binding
- GTPase activity
- calcium channel regulator activity