Ccr10 Gene Summary [Mouse]
Enables C-C chemokine receptor activity. Acts upstream of or within chemotaxis and positive regulation of cytosolic calcium ion concentration. Predicted to be located in cell surface; endoplasmic reticulum; and plasma membrane. Predicted to be active in external side of plasma membrane. Orthologous to human CCR10 (C-C motif chemokine receptor 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccr10 |
| Official Name | chemokine (C-C motif) receptor 10 [Source:MGI Symbol;Acc:MGI:1096320] |
| Ensembl ID | ENSMUSG00000044052 |
| Bio databases IDs | |
| Aliases | chemokine (C-C motif) receptor 10 |
| Synonyms | C-C CKR-10, C-C motif chemokine receptor 10, Cmkbr9, GPR2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccr10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- C-C chemokine receptor
- Cholecystokinin A receptor, N-terminal
- chemokine receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Ccr10 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ataxia
- paresis
- dysmyelination
- endometriosis
- hypermyelination
- metastasis
- chronic hepatitis
- muscle spasm
- gait disturbance
regulates
- Ca2+
- IgA
- NADPH oxidase
role in cell
- chemotaxis
- migration
- extravasation
- abnormal morphology
- trafficking
- elevation in
- establishment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ccr10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- G-protein coupled receptor signaling pathway
- chemokine-mediated signaling pathway
- calcium-mediated signaling
- cell chemotaxis
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- endoplasmic reticulum
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- C-C chemokine binding
- G-protein coupled receptor activity
- protein binding
- C-C chemokine receptor activity