Ccl28 Gene Summary [Mouse]
Enables chemokine activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide; cell chemotaxis; and killing of cells of another organism. Acts upstream of or within positive regulation of cytosolic calcium ion concentration. Predicted to be active in extracellular space. Predicted to colocalize with secretory granule. Orthologous to human CCL28 (C-C motif chemokine ligand 28). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccl28 |
| Official Name | chemokine (C-C motif) ligand 28 [Source:MGI Symbol;Acc:MGI:1861731] |
| Ensembl ID | ENSMUSG00000074715 |
| Bio databases IDs | |
| Aliases | chemokine (C-C motif) ligand 28 |
| Synonyms | CCK1, C-C motif chemokine ligand 28, MEC, SCYA28 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccl28 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the Ccl28 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric cancer
- breast carcinoma
- renal clear cell adenocarcinoma
- renal clear cell cancer
- primary sclerosing cholangitis
- dextran sodium sulfate-induced colitis
- alcoholic liver disease
- primary biliary cirrhosis
- gastric epithelial cancer
- airway hyperresponsiveness
role in cell
- migration
- accumulation
- number
- quantity
- binding
- killing
- chemotaxis
- adhesion
- recruitment
- viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- membrane surface
- Plasma Membrane
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ccl28 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemotaxis
- immune response
- positive regulation of cell-matrix adhesion
- signal transduction
- response to nutrient
- cell chemotaxis
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- chemokine activity