Kcnj4 Gene Summary [Mouse]

Enables inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane and regulation of monoatomic ion transmembrane transport. Is active in glutamatergic synapse and postsynaptic membrane. Is expressed in several structures, including adrenal gland; alimentary system; heart; telencephalon; and thymus. Orthologous to human KCNJ4 (potassium inwardly rectifying channel subfamily J member 4). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Kcnj4
Official Name
potassium inwardly-rectifying channel, subfamily J, member 4 [Source:MGI Symbol;Acc:MGI:104743]
Ensembl ID
ENSMUSG00000044216
Bio databases IDs NCBI: 16520 Ensembl: ENSMUSG00000044216
Aliases potassium inwardly-rectifying channel, subfamily J, member 4
Synonyms HIR, HIRK2, HRK1, IRK-3, Kcnf2, Kir2.3, MB-IRK3, potassium inwardly rectifying channel subfamily J member 4, potassium inwardly-rectifying channel, subfamily J, member 4
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcnj4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • inward rectifier potassium channel
  • cytoplasmic domain
  • Inward rectifier potassium channel C-terminal domain
  • Inward rectifier potassium channel transmembrane domain
  • protein binding
  • PDZ binding motif
  • ion channel
  • PDZ-domain binding

Pathways

Biological processes and signaling networks where the Kcnj4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • Huntington disease
  • conotruncal heart malformations
regulated by
regulates
  • NFkB (complex)
  • K+
role in cell
  • activation in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • membrane fraction
  • glutaminergic synapse
  • cellular membrane
  • postsynaptic membrane
  • basolateral membrane
  • perikaryon
  • dendrites
  • detergent-soluble fraction

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcnj4 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • potassium ion transport
  • regulation of ion transmembrane transport

Cellular Component

Where in the cell the gene product is active
  • cytoplasmic vesicle membrane
  • postsynaptic membrane
  • voltage-gated potassium channel complex
  • basolateral plasma membrane
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • PDZ domain binding
  • inward rectifier potassium channel activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.