Cxxc4 Gene Summary [Mouse]
Predicted to enable PDZ domain binding activity; methyl-CpG binding activity; and zinc ion binding activity. Acts upstream of or within Wnt signaling pathway. Located in cytoplasmic vesicle and nucleus. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; nervous system; and nose. Orthologous to human CXXC4 (CXXC finger protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Cxxc4 |
| Official Name | CXXC finger 4 [Source:MGI Symbol;Acc:MGI:2442112] |
| Ensembl ID | ENSMUSG00000044365 |
| Bio databases IDs | |
| Aliases | CXXC finger 4 |
| Synonyms | 9330210J02RIK, C030003J12RIK, CXXC finger 4, CXXC finger protein 4, Gm2095, IDAX |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cxxc4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- methyl-CpG binding
- CXXC motif
- protein binding
- CXXC zinc finger domain
- PDZ-domain binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- preeclampsia
- small cell lung cancer
- renal cell carcinoma
- renal cell cancer
role in cell
- activation in
- expression in
- proliferation
- upregulation in
- downregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cxxc4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- zygotic specification of dorsal/ventral axis
- Wnt receptor signaling pathway
- negative regulation of Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytoplasmic vesicle
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- PDZ domain binding
- methyl-CpG binding