Piwil2 Gene Summary [Mouse]
Enables RNA endonuclease activity; mRNA binding activity; and piRNA binding activity. Involved in several processes, including germ-line stem cell population maintenance; negative regulation of circadian rhythm; and regulation of gene expression. Acts upstream of with a positive effect on transposable element silencing by piRNA-mediated heterochromatin formation. Acts upstream of or within positive regulation of meiosis I. Located in several cellular components, including cytoplasmic ribonucleoprotein granule; dense body; and perinucleolar chromocenter. Part of PET complex. Is expressed in central nervous system; genitourinary system; and sensory organ. Orthologous to human PIWIL2 (piwi like RNA-mediated gene silencing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Piwil2 |
| Official Name | piwi-like RNA-mediated gene silencing 2 [Source:MGI Symbol;Acc:MGI:1930036] |
| Ensembl ID | ENSMUSG00000033644 |
| Bio databases IDs | |
| Aliases | piwi-like RNA-mediated gene silencing 2 |
| Synonyms | CT80, HILI, mili, PIWI2, PIWIL1L, piwi-like RNA-mediated gene silencing 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Piwil2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Piwi-like
- mRNA binding
- Argonaute linker 1 domain
- endoribonuclease
- PAZ domain
- enzyme
- protein binding
- PAZ
- Piwi domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ovarian cancer
- breast cancer
- azoospermia
- takotsubo cardiomyopathy
role in cell
- expression in
- proliferation
- apoptosis
- survival
- development
- quantity
- function
- prophase
- abnormal morphology
- early pachytene stage
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic ribonucleoprotein granule
- perinuclear region
- punctate structures
- Nucleus
- cytosol
- chromosome
- sister chromatids
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Piwil2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- meiotic cell cycle
- rhythmic process
- positive regulation of cytoplasmic translation
- positive regulation of meiosis I
- oogenesis
- germ-line stem cell maintenance
- spermatogenesis
- gene silencing by RNA
- negative regulation of circadian rhythm
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatoid body
- cytoplasm
- perinucleolar chromocenter
- P granule
- pi-body
Molecular Function
What the gene product does at the molecular level
- protein binding
- piRNA binding
- metal ion binding
- mRNA binding
- endoribonuclease activity