Lsm11 Gene Summary [Mouse]
Predicted to enable U7 snRNA binding activity. Involved in mRNA 3'-end processing by stem-loop binding activity and cleavage. Part of U7 snRNP and histone pre-mRNA 3'end processing complex. Is expressed in femur; nucleus pulposus; rib; thoracic segment skeleton; and turbinate bone primordium. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human LSM11 (LSM11, U7 small nuclear RNA associated). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lsm11 |
| Official Name | U7 snRNP-specific Sm-like protein LSM11 [Source:MGI Symbol;Acc:MGI:1919540] |
| Ensembl ID | ENSMUSG00000044847 |
| Bio databases IDs | |
| Aliases | U7 snRNP-specific Sm-like protein LSM11 |
| Synonyms | 2210404M20RIK, AGS8, LSM11, U7 small nuclear RNA associated, RGD1565523, U7 snRNP-specific Sm-like protein LSM11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lsm11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- snRNA binding
- Sm and related proteins
- protein binding
Pathways
Biological processes and signaling networks where the Lsm11 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lsm11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of G1/S transition of mitotic cell cycle
- histone mRNA 3'-end processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- histone pre-mRNA 3'end processing complex
- U7 snRNP
- telomerase holoenzyme complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- U7 snRNA binding