Snrpe Gene Summary [Mouse]
Predicted to enable U1 snRNP binding activity. Predicted to be involved in spliceosomal snRNP assembly. Predicted to be located in cytosol and nucleus. Predicted to be part of several cellular components, including methylosome; small nuclear ribonucleoprotein complex; and spliceosomal complex. Is expressed in central nervous system; sensory organ; and tooth. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; hypotrichosis 1; hypotrichosis 11; and lupus nephritis. Orthologous to human SNRPE (small nuclear ribonucleoprotein polypeptide E). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Snrpe |
| Official Name | small nuclear ribonucleoprotein E [Source:MGI Symbol;Acc:MGI:98346] |
| Ensembl ID | ENSMUSG00000090553 |
| Bio databases IDs | |
| Aliases | small nuclear ribonucleoprotein E |
| Synonyms | HYPT11, small nuclear ribonucleoprotein E, small nuclear ribonucleoprotein polypeptide E, SME, Sm protein E, snRNP-E |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Snrpe often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sm and related proteins
- ribonucleoprotein binding
- protein binding
Pathways
Biological processes and signaling networks where the Snrpe gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- epithelial cancer
- hypotrichosis type 11
- hepatocellular carcinoma
- liver cancer
- chronic kidney disease
regulated by
- streptozocin
- bisphenol A
- 5-fluorouracil
- Major late
- imatinib
- tretinoin
- CRYBA1
- RNase
- phenylephrine
- tanespimycin
role in cell
- cell death
- apoptosis
- expression in
- cell viability
- migration
- quantity
- proliferation
- splicing by
- invasion by
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- catalytic step 2 spliceosome
- cytosol
- spliceosomes
- nucleoplasm
- interchromatin granule clusters
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Snrpe gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spliceosomal complex assembly
- spliceosomal snRNP assembly
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- U5 snRNP
- spliceosomal complex
- U2-type spliceosomal complex
- U7 snRNP
- U2 snRNP
- telomerase holoenzyme complex
- U1 snRNP
- U4 snRNP
- nucleoplasm
- U12-type spliceosomal complex
- nucleus
- pICln-Sm protein complex
- catalytic step 2 spliceosome
- precatalytic spliceosome
- methylosome
- SMN-Sm protein complex
- U4/U6 x U5 tri-snRNP complex
- cytosol
- U2-type catalytic step 2 spliceosome
- U2-type precatalytic spliceosome
- small nuclear ribonucleoprotein complex
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding