Pclaf Gene Summary [Mouse]
Predicted to enable chromatin binding activity and molecular adaptor activity. Predicted to be involved in several processes, including DNA metabolic process; centrosome cycle; and response to UV. Predicted to be located in centrosome and perinuclear region of cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; central nervous system; facial prominence; limb; and skin. Orthologous to human PCLAF (PCNA clamp associated factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pclaf |
| Official Name | PCNA clamp associated factor [Source:MGI Symbol;Acc:MGI:1915276] |
| Ensembl ID | ENSMUSG00000040204 |
| Bio databases IDs | |
| Aliases | PCNA clamp associated factor |
| Synonyms | 2810417H13Rik, AA409629, KIAA0101, L5, mKIAA0101, Ns5apt9, NS5ATP9, OEATC, OEATC-1, p15PAF, p15/PAF, p15(PAF), PAF, PAF15, PCNA clamp associated factor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pclaf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PCNA-associated factor histone like domain
- chromatin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- liver cancer
- schizophrenia
- psoriasis
- pancreatic cancer
- organismal death
- hypoplasia
- primary ovarian cancer
- HER2 negative hormone receptor negative breast cancer
phenotypes
- decreased CD11b-high dendritic cell number
- decreased T cell number
- decreased dendritic cell number
- decreased immature NK cell number
- decreased plasmacytoid dendritic cell number
- decreased regulatory T cell number
- impaired glucose tolerance
- increased CD11b-low dendritic cell number
- increased dendritic cell number
- increased mature NK cell number
- increased memory CD4-positive CD25-positive alpha-beta regulatory T cell number
- increased pro-B cell number
- abnormal common lymphocyte progenitor cell morphology
- abnormal hematopoietic stem cell physiology
- abnormal hematopoietic system physiology
- decreased bone marrow cell number
- decreased common myeloid progenitor cell number
- decreased hematopoietic stem cell number
- decreased leukocyte cell number
- oxidative stress
- spleen hypoplasia
- thymus hypoplasia
role in cell
- quantity
- expression in
- apoptosis
- proliferation
- synthesis in
- accumulation in
- number
- growth
- development
- G1/S phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- centrosome
- nucleoplasm
- DNA replication foci
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pclaf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- centrosome cycle
- DNA replication
- response to UV
- regulation of cell cycle
- response to DNA damage stimulus
- translesion synthesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- perinuclear region of cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- chromatin binding
- binding, bridging