Dlx5 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including BMP signaling pathway; endochondral ossification; and osteoblast differentiation. Acts upstream of or within several processes, including embryonic morphogenesis; neuron differentiation; and regulation of gene expression. Located in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; nervous system; and sensory organ. Used to study split hand-foot malformation 1. Human ortholog(s) of this gene implicated in split hand-foot malformation 1 and split hand-foot malformation 1 with sensorineural hearing loss. Orthologous to human DLX5 (distal-less homeobox 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dlx5 |
| Official Name | distal-less homeobox 5 [Source:MGI Symbol;Acc:MGI:101926] |
| Ensembl ID | ENSMUSG00000029755 |
| Bio databases IDs | |
| Aliases | distal-less homeobox 5 |
| Synonyms | BAC CLONE RG300E22, distal-less homeobox 5, Distal-less-like homeoprotein, RDLX, SHFM1, SHFM1D |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dlx5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- DNA binding domain
- nucleic acid binding
- Homeobox protein distal-less-like N terminal
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- Dlx homology domain
- double-stranded DNA binding
- homeodomain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Dlx5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypoplasia
- split hand/foot malformation type 1
- Alzheimer disease
- osteosarcoma
- osteosarcomagenesis
- split-hand/foot malformation 1 with sensorineural hearing loss
- exencephaly
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- syndromic microphthalmia 2
phenotypes
- Wormian bones
- abnormal GABAergic neuron morphology
- abnormal Meckel's cartilage morphology
- abnormal alisphenoid bone morphology
- abnormal axon extension
- abnormal basicranium morphology
- abnormal basioccipital bone morphology
- abnormal basisphenoid bone morphology
- abnormal bone ossification
- abnormal brain development
- abnormal cell proliferation
- abnormal cochlea morphology
- abnormal craniofacial bone morphology
- abnormal craniofacial development
- abnormal cranium morphology
- abnormal crista ampullaris morphology
- abnormal crista ampullaris neuroepithelium morphology
- abnormal digit morphology
- abnormal epitympanic recess morphology
- abnormal external auditory canal morphology
- abnormal first pharyngeal arch morphology
- abnormal frontal bone morphology
- abnormal frontonasal prominence morphology
- abnormal gonial bone morphology
- abnormal head development
- abnormal hindlimb morphology
- abnormal hyoid bone greater horn morphology
- abnormal hyoid bone lesser horn morphology
- abnormal hyoid bone morphology
- abnormal incisor morphology
- abnormal inner ear vestibule morphology
- abnormal interparietal bone morphology
- abnormal intrinsic tongue muscle morphology
- abnormal jaw morphology
- abnormal lacrimal bone morphology
- abnormal larynx morphology
- abnormal lateral nasal prominence morphology
- abnormal malleus morphology
- abnormal mandible morphology
- abnormal mandibular angle morphology
- abnormal mandibular condyloid process morphology
- abnormal mandibular coronoid process morphology
- abnormal mandibular prominence morphology
- abnormal maxilla morphology
- abnormal metatarsal bone morphology
- abnormal middle ear morphology
- abnormal middle ear ossicle morphology
- abnormal mitral cell morphology
- abnormal molar crown morphology
- abnormal molar morphology
- abnormal mouth morphology
- abnormal mylohyoid muscle morphology
- abnormal nasal bone morphology
- abnormal nasal capsule morphology
- abnormal nasal mucosa morphology
- abnormal nasal pit morphology
- abnormal neurocranium morphology
- abnormal occipital bone morphology
- abnormal olfactory bulb granule cell morphology
- abnormal olfactory bulb morphology
- abnormal olfactory bulb periglomerular cell morphology
- abnormal olfactory epithelium morphology
- abnormal olfactory nerve morphology
- abnormal osteoblast differentiation
- abnormal otic capsule morphology
- abnormal outer ear cartilage morphology
- abnormal outer ear morphology
- abnormal palate morphology
- abnormal parietal bone morphology
- abnormal phalanx morphology
- abnormal pharyngeal arch morphology
- abnormal premaxilla morphology
- abnormal pterygoid bone morphology
- abnormal pterygoid muscle morphology
- abnormal pterygoid process morphology
- abnormal rib morphology
- abnormal rostral migratory stream morphology
- abnormal scala vestibuli morphology
- abnormal semicircular canal morphology
- abnormal sensory neuron innervation pattern
- abnormal sexual interaction
- abnormal snout morphology
- abnormal stapedial artery morphology
- abnormal stylohyoid ligament morphology
- abnormal styloid process morphology
- abnormal suckling behavior
- abnormal superior horn of thyroid cartilage morphology
- abnormal tegmen tympani morphology
- abnormal temporal bone squamous part morphology
- abnormal thyroid cartilage morphology
- abnormal tongue muscle morphology
- abnormal tooth mineralization
- abnormal utricular macula morphology
- abnormal vestibular saccular macula morphology
- abnormal vestibular saccule morphology
- abnormal vibrissa morphology
- abnormal viscerocranium morphology
- abnormal vomer bone morphology
- abnormal zygomatic bone morphology
- absent Meckel's cartilage
- absent endolymphatic duct
- absent gastric milk in neonates
- absent mandibular coronoid process
- absent olfactory epithelium
- absent palatine bone horizontal plate
- absent posterior semicircular canal
- absent semicircular canals
- absent stapes
- absent superior semicircular canal
- absent vomeronasal organ
- anencephaly
- brachydactyly
- cleft primary palate
- cleft secondary palate
- decreased body size
- decreased bone mineralization
- decreased cochlear coiling
- decreased lateral semicircular canal size
- decreased maxillary shelf size
- decreased tympanic ring size
- delayed bone ossification
- delayed cranial suture closure
- deviated nasal septum
- distended abdomen
- ectopic cartilage
- ectopic cranial bone
- ectrodactyly
- enlarged utricle
- exencephaly
- frontonasal prominence hypoplasia
- fused pharyngeal arches
- hypoactivity
- large anterior fontanelle
- lower jaw to upper jaw transformation
- meteorism
- micrognathia
- neonatal lethality complete penetrance
- no abnormal phenotype detected
- open neural tube
- otic capsule hypoplasia
- otic vesicle hypoplasia
- perinatal lethality
- perinatal lethality complete penetrance
- postnatal lethality complete penetrance
- prenatal lethality incomplete penetrance
- respiratory distress
- short Meckel's cartilage
- short endolymphatic duct
- short lower incisors
- short mandible
- short maxilla
- short nasal bone
- short nasal septum
- short premaxilla
- short snout
- short styloid process
- short upper incisors
- small interparietal bone
- small lacrimal bone
- small malleus processus brevis
- small maxilla
- small nasal bone
- small olfactory bulb
- small parietal bone
- small presphenoid bone
- small supraoccipital bone
- small trigeminal ganglion
- small vomer bone
- small vomeronasal organ
- syndactyly
- turbinate hypoplasia
- wide cranial sutures
role in cell
- proliferation
- differentiation
- development
- guidance
- outgrowth
- endochondral ossification by
- morphogenesis
- abnormal morphology
- production
- developmental process
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dlx5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- embryo development
- olfactory pit development
- olfactory bulb interneuron differentiation
- palate development
- nervous system development
- positive regulation of canonical Wnt receptor signaling pathway
- anatomical structure formation involved in morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- face morphogenesis
- regulation of transcription from RNA polymerase II promoter
- epithelial cell differentiation
- embryonic limb morphogenesis
- skeletal system development
- positive regulation of transcription, DNA-dependent
- BMP signaling pathway
- positive regulation of gene expression
- inner ear morphogenesis
- osteoblast differentiation
- cell differentiation
- endochondral ossification
- positive regulation of epithelial cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromatin
Molecular Function
What the gene product does at the molecular level
- HMG box domain binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity