Kcna5 Gene Summary [Mouse]
Enables voltage-gated potassium channel activity. Acts upstream of or within Notch signaling pathway; regulation of membrane potential; and regulation of vasoconstriction. Located in intercalated disc and plasma membrane. Is expressed in several structures, including gut; heart; metanephros; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in familial atrial fibrillation and pulmonary hypertension. Orthologous to human KCNA5 (potassium voltage-gated channel subfamily A member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcna5 |
| Official Name | potassium voltage-gated channel, shaker-related subfamily, member 5 [Source:MGI Symbol;Acc:MGI:96662] |
| Ensembl ID | ENSMUSG00000045534 |
| Bio databases IDs | |
| Aliases | potassium voltage-gated channel, shaker-related subfamily, member 5 |
| Synonyms | ATFB7, HCK1, HK2, HPCN1, Kv1, KV1.5, KV1.5 alpha subunit, KV1.5 α subunit, PCN1, potassium voltage-gated channel, shaker-related subfamily, member 5, potassium voltage-gated channel subfamily A member 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcna5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- outward rectifier potassium channel
- delayed rectifier potassium channel
- protein kinase binding
- Ion transport protein
- actinin binding
- BTB_POZ
- protein binding
- receptor binding
- proline rich domain
- ion channel
- voltage-gated potassium channel
- subregion I of the P region
- Broad-Complex, Tramtrack and Bric a brac
Pathways
Biological processes and signaling networks where the Kcna5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- malaria
- cardiovascular disorder
- Huntington disease
- hemodynamically unstable ventricular tachycardia
- paroxysmal atrial fibrillation
- atrial flutter
- atrial fibrillation
- Alzheimer disease
- multiple sclerosis
regulates
- nitric oxide
- vernakalant
- K+
- hormone
- flecainide
- insulin
role in cell
- apoptosis
- proliferation
- cell death
- transmembrane potential
- abnormal morphology
- hyperpolarization
- contraction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- perinuclear region
- cellular membrane
- intercellular junctions
- caveolae
- intercalated disks
- Z line
- membrane rafts
- membrane processes
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcna5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to hyperoxia
- regulation of atrial cardiac muscle cell action potential
- potassium ion transmembrane transport
- potassium ion homeostasis
- positive regulation of G1/S transition of mitotic cell cycle
- regulation of atrial cardiomyocyte membrane repolarization
- protein homooligomerization
- regulation of potassium ion transport
- reduction of cytosolic calcium ion concentration
- response to hydrogen peroxide
- response to mechanical stimulus
- potassium ion transport
- regulation of insulin secretion
- regulation of membrane potential
- Notch signaling pathway
- response to hypoxia
- membrane hyperpolarization
- positive regulation of myoblast proliferation
- membrane repolarization involved in regulation of bundle of His cardiac muscle cell action potential
- regulation of action potential
- regulation of heart rate by cardiac conduction
- regulation of vasoconstriction
- membrane repolarization involved in regulation of SA node cardiac muscle cell action potential
Cellular Component
Where in the cell the gene product is active
- voltage-gated potassium channel complex
- Golgi apparatus
- plasma membrane
- cell surface
- intracellular canaliculus
- Z disc
- caveola
- potassium channel complex
- perinuclear region of cytoplasm
- membrane raft
- membrane
- intercalated disc
Molecular Function
What the gene product does at the molecular level
- scaffold protein binding
- protein kinase binding
- protein binding
- voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization
- voltage-gated potassium channel activity involved in SA node cell action potential repolarization
- delayed rectifier potassium channel activity
- alpha-actinin binding
- outward rectifier potassium channel activity
- voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization
- receptor binding