Pdgfb Gene Summary [Mouse]
Predicted to enable several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and receptor ligand activity. Involved in several processes, including cellular response to platelet-derived growth factor stimulus; metanephric glomerulus vasculature development; and paracrine signaling. Acts upstream of or within several processes, including nervous system development; salivary gland morphogenesis; and vasculature development. Predicted to be located in several cellular components, including basolateral plasma membrane; cell surface; and neuronal cell body. Predicted to be part of platelet-derived growth factor complex. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; extraembryonic component; female reproductive system; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including basal ganglia calcification; clear cell renal cell carcinoma; dermatofibrosarcoma protuberans; familial meningioma; and high grade glioma (multiple). Orthologous to human PDGFB (platelet derived growth factor subunit B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pdgfb |
| Official Name | platelet derived growth factor, B polypeptide [Source:MGI Symbol;Acc:MGI:97528] |
| Ensembl ID | ENSMUSG00000000489 |
| Bio databases IDs | |
| Aliases | platelet derived growth factor, B polypeptide |
| Synonyms | c-sis, IBGC5, PDGF-2, PDGF-BB, PDGF beta, PDGFbetaR, Pdgfrb, PDGFRbeta, PDGF β, platelet derived growth factor, B polypeptide, platelet derived growth factor subunit B, SIS, SSV |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pdgfb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- superoxide-generating NADPH oxidase activator
- Platelet-derived growth factor, N terminal region
- chemoattractant
- platelet-derived growth factor receptor binding
- protein binding
- receptor binding
- identical protein binding
- growth factor
- retention sequence
- PDGF
- transmembrane domain
- collagen binding
- protein homodimerization
- protein heterodimerization
- growth factor binding
Pathways
Biological processes and signaling networks where the Pdgfb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Atherosclerosis Signaling
- Autophagy
- Breast Cancer Regulation by Stathmin1
- Clathrin-mediated Endocytosis Signaling
- CREB Signaling in Neurons
- Ephrin A Signaling
- Ephrin Receptor Signaling
- Glioblastoma Multiforme Signaling
- Glioma Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HIF1α Signaling
- Human Embryonic Stem Cell Pluripotency
- Integrin Signaling
- Iron homeostasis signaling pathway
- Macropinocytosis Signaling
- PAK Signaling
- PDGF Signaling
- PPAR Signaling
- Renal Cell Carcinoma Signaling
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of PKR in Interferon Induction and Antiviral Response
- Sphingosine-1-phosphate Signaling
- STAT3 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- chronic myeloid leukemia
- astrocytosis
- prostatic neoplasm
- adenocarcinoma
- metastasis
- precursor B-cell acute lymphoblastic leukemia
- Philadelphia-like B-cell acute lymphoblastic leukemia
- chronic phase chronic myeloid leukemia
- T acute lymphoblastic leukemia
role in cell
- morphology
- quantity
- activation in
- proliferation
- survival
- differentiation
- expression in
- activation
- production in
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- Cytoplasm
- cell surface
- endoplasmic reticulum lumen
- basolateral membrane
- Golgi membrane
- alpha granules
- perikaryon
- dendrites
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pdgfb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-tyrosine phosphorylation
- protein kinase C signaling cascade
- positive chemotaxis
- positive regulation of mitosis
- negative regulation of protein binding
- cell chemotaxis
- positive regulation of protein autophosphorylation
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- positive regulation of cell-substrate adhesion
- positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
- cellular response to platelet-derived growth factor stimulus
- platelet-derived growth factor receptor signaling pathway
- negative regulation of gene expression
- metanephric glomerular mesangial cell development
- positive regulation of gene expression
- cellular response to growth factor stimulus
- gene expression
- negative regulation of platelet activation
- positive regulation of chemotaxis
- positive regulation of protein kinase B signaling cascade
- positive regulation of cell migration
- positive regulation of MAP kinase activity
- hemopoiesis
- positive regulation of cell proliferation
- response to wounding
- protein phosphorylation
- embryonic placenta development
- positive regulation of smooth muscle cell proliferation
- positive regulation of glomerular filtration
- heart development
- positive regulation of cell division
- positive regulation of fibroblast proliferation
- negative regulation of phosphatidylinositol biosynthetic process
- positive regulation of glomerular mesangial cell proliferation
- positive regulation of smooth muscle cell migration
- positive regulation of DNA biosynthetic process
- interleukin-18-mediated signaling pathway
- positive regulation of reactive oxygen species metabolic process
- positive regulation of metanephric mesenchymal cell migration
- paracrine signaling
- positive regulation of MAPK cascade
- positive regulation of hyaluronan biosynthetic process
- positive regulation of blood vessel endothelial cell migration
- positive regulation of calcium ion import
- reactive oxygen species metabolic process
- monocyte chemotaxis
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of endothelial cell proliferation
- cellular response to mycophenolic acid
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- endoplasmic reticulum lumen
- extracellular space
- cytoplasm
- Golgi membrane
- Golgi lumen
- extracellular region
- basolateral plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- growth factor activity
- protein binding
- protein homodimerization activity
- collagen binding
- platelet-derived growth factor receptor binding
- protein heterodimerization activity
- chemoattractant activity
- superoxide-generating NADPH oxidase activator activity
- platelet-derived growth factor binding