Lrrc8d Gene Summary [Mouse]
Enables volume-sensitive anion channel activity. Involved in intracellular glucose homeostasis. Located in plasma membrane. Is expressed in several structures, including nasal cavity epithelium; nervous system; submandibular gland primordium; tooth; and vibrissa. Orthologous to human LRRC8D (leucine rich repeat containing 8 VRAC subunit D). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lrrc8d |
| Official Name | leucine rich repeat containing 8D [Source:MGI Symbol;Acc:MGI:1922368] |
| Ensembl ID | ENSMUSG00000046079 |
| Bio databases IDs | |
| Aliases | leucine rich repeat containing 8D |
| Synonyms | 2810473G09RIK, 4930525N13Rik, A930019F03, HsLRRC8D, leucine rich repeat containing 8D, leucine rich repeat containing 8 VRAC subunit D, LRRC5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lrrc8d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- volume-sensitive anion channel
- protein phosphatase 1 regulatory subunit 42
- Leucine rich repeat
- protein binding
- Leucine Rich repeats (2 copies)
- Pannexin-like TM region of LRRC8
Pathways
Biological processes and signaling networks where the Lrrc8d gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung squamous cell carcinoma
- squamous cell lung cancer
- digestive system disorder
- lung carcinoma
- lung carcinoma process
- productive infection by HIV-1
regulates
- D-glucose
- taurine
- blasticidin S
- anion
- L-aspartic acid
role in cell
- response by
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lrrc8d gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to osmotic stress
- cellular glucose homeostasis
- protein hexamerization
- taurine transport
- aspartate transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasm
- membrane
- ion channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- volume-sensitive anion channel activity