Fut10 Gene Summary [Mouse]
Enables alpha-(1->3)-fucosyltransferase activity. Involved in N-glycan fucosylation and neuronal stem cell division. Acts upstream of or within cerebral cortex radially oriented cell migration; neuroblast migration; and neuronal stem cell population maintenance. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and nucleoplasm. Predicted to be active in endoplasmic reticulum membrane. Is expressed in central nervous system and retina. Orthologous to human FUT10 (fucosyltransferase 10). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fut10 |
| Official Name | fucosyltransferase 10 [Source:MGI Symbol;Acc:MGI:2384748] |
| Ensembl ID | ENSMUSG00000046152 |
| Bio databases IDs | |
| Aliases | fucosyltransferase 10 |
| Synonyms | alpha 1,3-fucosyl transferase, fucosyltransferase 10, FUCTX, fut10A, α 1,3-fucosyl transferase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fut10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptide-O-fucosyltransferase
- alpha(1,3)-fucosyltransferase
- Fucosyltransferase, N-terminal
- fucosyltransferase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fut10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- hemopoiesis
- fucosylation
- nervous system development
- protein glycosylation
- N-glycan fucosylation
- fertilization
- cerebral cortex radially oriented cell migration
- oligosaccharide biosynthetic process
- L-fucose catabolic process
- protein folding
- neuronal stem cell maintenance
- protein targeting
- wound healing
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
- Golgi apparatus
- Golgi membrane
- nucleoplasm
- lysosome
Molecular Function
What the gene product does at the molecular level
- alpha-(1->3)-fucosyltransferase activity