Pltp Gene Summary [Mouse]
Enables lipid transfer activity. Acts upstream of or within flagellated sperm motility and vitamin E biosynthetic process. Located in extracellular space. Is expressed in several structures, including bone marrow; central nervous system; genitourinary system; humerus cartilage condensation; and oral region epithelium. Used to study dry eye syndrome. Orthologous to human PLTP (phospholipid transfer protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pltp |
| Official Name | phospholipid transfer protein [Source:MGI Symbol;Acc:MGI:103151] |
| Ensembl ID | ENSMUSG00000017754 |
| Bio databases IDs | |
| Aliases | phospholipid transfer protein |
| Synonyms | BPIFE, HDLCQ9, Lipid transfer protein II, OD107, phospholipid transfer protein, Plasma phospholipid transfer, Pltp1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pltp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- glycolipid transporter
- sphingolipid binding
- lipid binding domain
- phospholipid transporter
- phosphatidylethanolamine binding
- high-density lipoprotein binding
- phosphatidylinositol transporter
- enzyme
- low-density lipoprotein binding
- protein binding
- BPI
- lipid transporter
- binding protein
- phosphatidylcholine transporter
- diacylglycerol binding
- sphingolipid transporter
Pathways
Biological processes and signaling networks where the Pltp gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- diabetes mellitus
- abdominal aortic aneurysm
- Alzheimer disease
- Waldenström macroglobulinemia
- androgenic alopecia
- compulsive gambling
- dry eye
- systemic lupus erythematosus
- coronary artery disease
role in cell
- cytotoxicity
- function
- adhesion
- activity
- cellular infiltration by
- colony formation by
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- Nucleus
- Endoplasmic Reticulum
- granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pltp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid transport
- sperm motility
- high-density lipoprotein particle remodeling
- sterol transport
- lipid metabolic process
- positive regulation of cholesterol efflux
- phospholipid transport
- ceramide transport
- vitamin E biosynthetic process
- glycolipid transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- high-density lipoprotein particle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- ceramide binding
- phosphatidylethanolamine binding
- very-low-density lipoprotein particle binding
- diacylglycerol binding
- phosphatidic acid binding
- high-density lipoprotein particle binding
- phosphatidylcholine binding
- phosphatidylinositol transporter activity
- low-density lipoprotein particle binding