Rbp1 Gene Summary [Rat]
This gene encodes the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Details
| Type | Protein Coding |
| Official Symbol | Rbp1 |
| Official Name | retinol binding protein 1 [Source:RGD Symbol;Acc:3543] |
| Ensembl ID | ENSRNOG00000013794 |
| Bio databases IDs | |
| Aliases | retinol binding protein 1 |
| Synonyms | CRABP-I, CRBP, CRBP1, CRBPI, hCRBP1, LOC100045055, RBPC, retinol binding protein 1, retinol binding protein 1, cellular |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rbp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- helical cap
- lipocalin/cytosolic fatty acid-binding protein family
- retinol binding
- protein binding
- retinoid binding
- Lipocalin / cytosolic fatty-acid binding protein family
- transporter
Pathways
Biological processes and signaling networks where the Rbp1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- hyperplasia
- organismal death
- uterine leiomyoma
- leiomyomatosis
- hyperglycemia
- aortic valve calcification
- growth failure
role in cell
- number
- expression in
- survival
- differentiation
- proliferation
- migration
- binding
- accumulation in
- cellular infiltration by
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- nuclear fraction
- Cytoplasm
- Nucleus
- lipid droplets
- cytosol
- nucleoplasm
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rbp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retinoic acid biosynthetic process
- fatty acid transport
- lipid homeostasis
- vitamin A metabolic process
Cellular Component
Where in the cell the gene product is active
- lipid particle
- nucleus
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- fatty acid binding
- protein binding
- retinal binding
- retinoid binding