Kctd11 Gene Summary [Mouse]
Predicted to enable identical protein binding activity. Acts upstream of or within several processes, including negative regulation of neuroblast proliferation; negative regulation of smoothened signaling pathway; and positive regulation of neuron differentiation. Located in cytoplasm. Is expressed in several structures, including 1st branchial arch; central nervous system; ectoplacental cone; primitive streak; and sensory organ. Orthologous to human KCTD11 (potassium channel tetramerization domain containing 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kctd11 |
| Official Name | potassium channel tetramerisation domain containing 11 [Source:MGI Symbol;Acc:MGI:2448712] |
| Ensembl ID | ENSMUSG00000046731 |
| Bio databases IDs | |
| Aliases | potassium channel tetramerisation domain containing 11 |
| Synonyms | AF465352, C17orf36, KCASH1, potassium channel tetramerisation domain containing 11, potassium channel tetramerization domain containing 11, REN, REN/KCTD11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kctd11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- BTB/POZ domain-containing protein KCTD11/21 C-terminus
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- medulloblastoma
- brain cancer
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
role in cell
- proliferation
- growth
- differentiation
- colony formation
- contact growth inhibition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kctd11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein homooligomerization
- positive regulation of neuron differentiation
- protein ubiquitination
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- transferase activity