Kctd11 Gene Summary [Rat]
Predicted to enable identical protein binding activity. Predicted to be involved in positive regulation of neuron differentiation. Predicted to act upstream of or within negative regulation of neuroblast proliferation; negative regulation of smoothened signaling pathway; and nervous system development. Predicted to be located in cytoplasm. Orthologous to human KCTD11 (potassium channel tetramerization domain containing 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kctd11 |
| Official Name | potassium channel tetramerization domain containing 11 [Source:RGD Symbol;Acc:1307125] |
| Ensembl ID | ENSRNOG00000015669 |
| Bio databases IDs | |
| Aliases | potassium channel tetramerization domain containing 11 |
| Synonyms | AF465352, C17orf36, KCASH1, potassium channel tetramerisation domain containing 11, potassium channel tetramerization domain containing 11, REN, REN/KCTD11 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kctd11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- BTB/POZ domain-containing protein KCTD11/21 C-terminus
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- medulloblastoma
- brain cancer
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
role in cell
- proliferation
- growth
- differentiation
- colony formation
- contact growth inhibition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kctd11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein homooligomerization
- positive regulation of neuron differentiation
- protein ubiquitination
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- transferase activity