Abhd17b Gene Summary [Mouse]
Enables palmitoyl-(protein) hydrolase activity. Involved in protein depalmitoylation; regulation of dendritic spine maintenance; and regulation of protein localization. Located in plasma membrane; postsynaptic density; and recycling endosome membrane. Orthologous to human ABHD17B (abhydrolase domain containing 17B, depalmitoylase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Abhd17b |
| Official Name | abhydrolase domain containing 17B [Source:MGI Symbol;Acc:MGI:1917816] |
| Ensembl ID | ENSMUSG00000047368 |
| Bio databases IDs | |
| Aliases | abhydrolase domain containing 17B |
| Synonyms | 5730446C15Rik, abhydrolase domain containing 17B, abhydrolase domain containing 17B, depalmitoylase, C9orf77, CGI-67, Cgi67l, Fam108b, FAM108B1, RGD1305246 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Abhd17b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Prolyl oligopeptidase family
- alpha/beta hydrolases
- Phospholipase/Carboxylesterase
- Serine aminopeptidase, S33
- peptidase
- palmitoyl-(protein) hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- synaptic membrane
- endosomal membrane
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Abhd17b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein depalmitoylation
Cellular Component
Where in the cell the gene product is active
- membrane
- dendritic spine
- endosome membrane
- recycling endosome membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- palmitoyl-(protein) hydrolase activity