Tnfrsf11b Gene Summary [Mouse]
Enables heparan sulfate binding activity. Involved in negative regulation of osteoclast differentiation. Acts upstream of or within extracellular matrix organization; negative regulation of odontogenesis of dentin-containing tooth; and negative regulation of tumor necrosis factor-mediated signaling pathway. Located in extracellular matrix. Is expressed in several structures, including arterial system; bone; gut; hemolymphoid system gland; and placenta. Used to study osteoporosis. Human ortholog(s) of this gene implicated in Paget's disease of bone; Paget's disease of bone 5; and osteoarthritis. Orthologous to human TNFRSF11B (TNF receptor superfamily member 11b). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnfrsf11b |
| Official Name | tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) [Source:MGI Symbol;Acc:MGI:109587] |
| Ensembl ID | ENSMUSG00000063727 |
| Bio databases IDs | |
| Aliases | tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) |
| Synonyms | OCIF, OPG, Osteoprotegerin, PDB5, TNFR11, TNF receptor superfamily member 11B, TR1, tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin), tumour necrosis factor receptor superfamily, member 11b (osteoprotegerin) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnfrsf11b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death domain
- extracellular domain
- signaling receptor activity
- TNFR/NGFR cysteine-rich region
- heparin binding domain
- protein binding
- Tumor necrosis factor receptor superfamily (TNFRSF)
- glycosaminoglycan binding
- binding protein
- basic domain
- Death Domain Superfamily of protein-protein interaction domains
- transmembrane receptor
- cysteine rich domain
Pathways
Biological processes and signaling networks where the Tnfrsf11b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- Autophagy
- Ceramide Signaling
- Dendritic Cell Maturation
- Docosahexaenoic Acid (DHA) Signaling
- Granulocyte Adhesion and Diapedesis
- Hepatic Cholestasis
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HMGB1 Signaling
- IL-17 Signaling
- IL-6 Signaling
- Induction of Apoptosis by HIV1
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- Myc Mediated Apoptosis Signaling
- NF-κB Signaling
- PPAR Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of Tissue Factor in Cancer
- T Helper Cell Differentiation
- Tight Junction Signaling
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colitis
- neoplasia
- osteoporosis
- osteopetrosis
- juvenile-onset Paget disease of bone 5
- osteoarthropathy
- diabetes mellitus
- compression fracture
- metastasis
- fibrosis
role in cell
- expression in
- activation in
- proliferation
- apoptosis
- activity
- phosphorylation in
- morphology
- production in
- cell death
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- extracellular matrix
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnfrsf11b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to estrogen stimulus
- signal transduction
- response to nutrient
- response to xenobiotic stimulus
- negative regulation of bone resorption
- negative regulation of odontogenesis of dentin-containing tooth
- skeletal system development
- response to arsenic-containing substance
- negative regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of osteoclast differentiation
- apoptotic process
- extracellular matrix organization
- response to magnesium ion
Cellular Component
Where in the cell the gene product is active
- extracellular space
- receptor complex
- extracellular matrix
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity
- cytokine activity