Tfr2 Gene Summary [Mouse]
Predicted to enable co-receptor binding activity and transferrin receptor activity. Acts upstream of or within multicellular organismal-level iron ion homeostasis. Part of HFE-transferrin receptor complex. Is expressed in liver lobe; mesonephros; and urinary system. Used to study hemochromatosis type 3. Human ortholog(s) of this gene implicated in hemochromatosis and hemochromatosis type 3. Orthologous to human TFR2 (transferrin receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tfr2 |
| Official Name | transferrin receptor 2 [Source:MGI Symbol;Acc:MGI:1354956] |
| Ensembl ID | ENSMUSG00000029716 |
| Bio databases IDs | |
| Aliases | transferrin receptor 2 |
| Synonyms | HFE3, TFRC2, TR2, transferrin receptor 2, Trfr2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tfr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Zinc peptidases M18, M20, M28, and M42
- cytoplasmic domain
- PA
- ectodomain
- transmembrane domain
- Transferrin receptor-like dimerization domain
- transferrin receptor
- protein binding
- Peptidase family M28
- transporter
Pathways
Biological processes and signaling networks where the Tfr2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- gastroesophageal reflux
- hypochromia
- hereditary hemochromatosis
- hereditary hemochromatosis type 3
- Burkitt lymphoma
- anemia
- colorectal cancer
- hemochromatosis
- survival
role in cell
- expression in
- apoptosis
- quantity
- number
- production in
- differentiation
- colony formation
- response by
- endocytosis by
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cell borders
- cellular membrane
- Endoplasmic Reticulum
- plasma membrane extracellular face
- basolateral membrane
- perinuclear space
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tfr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular iron ion homeostasis
- multicellular organismal iron ion homeostasis
- transferrin transport
- positive regulation of endocytosis
- iron ion transport
- positive regulation of peptide hormone secretion
- response to iron ion
- positive regulation of transcription from RNA polymerase II promoter
- acute-phase response
- cellular response to iron ion
- receptor-mediated endocytosis
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- cytoplasmic vesicle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- transferrin receptor activity
- protein binding