Cltb Gene Summary [Mouse]
Predicted to enable clathrin heavy chain binding activity and peptide binding activity. Predicted to be involved in clathrin-dependent endocytosis. Located in ciliary membrane and trans-Golgi network. Is expressed in central nervous system; dorsal root ganglion; liver; and neural retina. Orthologous to human CLTB (clathrin light chain B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cltb |
| Official Name | clathrin, light polypeptide (Lcb) [Source:MGI Symbol;Acc:MGI:1921575] |
| Ensembl ID | ENSMUSG00000047547 |
| Bio databases IDs | |
| Aliases | clathrin, light polypeptide (Lcb) |
| Synonyms | 2310046E19Rik, CLATHRIN, clathrin light chain B, clathrin, light chain B, CLTLB, LCB |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cltb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptide binding
- Clathrin light chain
- protein binding
Pathways
Biological processes and signaling networks where the Cltb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- schizophrenia
- medulloblastoma
- brain cancer
- acute graft-vs-host disease
- aortic valve calcification
- infection by Dengue virus 2
role in cell
- quantity
- endocytosis
- internalization by
- internalization
- internalization in
- replenishment in
- replenishment
- synaptic transmission in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic vesicle membrane
- annular gap junction vesicle
- intracellular membrane-bounded organelle
- Cytoplasm
- cilia
- cellular membrane
- Golgi Apparatus
- cytosol
- synaptic membrane
- trans Golgi network
- gap junctions
- clathrin-coated pits
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cltb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- clathrin-mediated endocytosis
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- clathrin coat
- trans-Golgi network
- clathrin coat of trans-Golgi network vesicle
- intracellular membrane-bounded organelle
- clathrin coat of coated pit
- cytosol
- cilium membrane
- clathrin-coated endocytic vesicle
- synaptic vesicle membrane
- clathrin vesicle coat
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- clathrin heavy chain binding
- protein binding
- structural molecule activity
- peptide binding