Diras2 Gene Summary [Mouse]
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in signal transduction. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; cerebellum external granule cell layer; intestine; liver; and retina layer. Orthologous to human DIRAS2 (DIRAS family GTPase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Diras2 |
| Official Name | DIRAS family, GTP-binding RAS-like 2 [Source:MGI Symbol;Acc:MGI:1915453] |
| Ensembl ID | ENSMUSG00000047842 |
| Bio databases IDs | |
| Aliases | DIRAS family, GTP-binding RAS-like 2 |
| Synonyms | 2900052J15RIK, AI414999, DIRAS family GTPase 2, DIRAS family, GTP-binding RAS-like 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Diras2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- 50S ribosome-binding GTPase
- GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- GTP binding
- small GTP-binding protein domain
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Alzheimer disease
- Huntington disease
- colorectal cancer
- organismal death
- covid-19 death
- Parkinson disease
- colon adenocarcinoma
- colon epithelial cancer
- renal clear cell adenocarcinoma
role in cell
- phosphorylation in
- proliferation
- expression in
- migration
- vacuolation
- invasion by
- Gap 0-Gap 1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Diras2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- signal transduction
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- GDP binding