Insc Gene Summary [Mouse]
Predicted to enable cytoskeletal anchor activity and protein domain specific binding activity. Predicted to be involved in apical protein localization; regulation of asymmetric cell division; and regulation of protein stability. Predicted to be located in plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in apical cortex. Predicted to colocalize with cell cortex. Is expressed in bone; lung epithelium; metanephros; and nervous system. Orthologous to human INSC (INSC spindle orientation adaptor protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Insc |
| Official Name | INSC spindle orientation adaptor protein [Source:MGI Symbol;Acc:MGI:1917942] |
| Ensembl ID | ENSMUSG00000048782 |
| Bio databases IDs | |
| Aliases | INSC spindle orientation adaptor protein |
| Synonyms | 3830422K02Rik, C730020D23, INSC spindle orientation adaptor protein, INSC, spindle orientation adaptor protein, RGD1311379 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Insc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Inscuteable LGN-binding domain
- protein binding activity, bridging
- protein domain specific binding
- protein binding
- LGN-binding domain (LBD) of protein Inscuteable (INSC) and similar proteins
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sporadic parathyroid adenoma
- parathyroid adenoma
role in cell
- expression in
- number
- metaphase/anaphase transition
- orientation in
- misorientation in
- orientation
- misorientation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell cortex
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Insc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- establishment of mitotic spindle orientation
- regulation of protein stability
- apical protein localization
- cell differentiation
- nervous system development
- regulation of asymmetric cell division
- asymmetric cell division
Cellular Component
Where in the cell the gene product is active
- cell cortex
- macromolecular complex
- apical cortex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- cytoskeletal adaptor activity
- protein binding, bridging