INSC Gene Summary [Human]
In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | INSC |
| Official Name | INSC spindle orientation adaptor protein [Source:HGNC Symbol;Acc:HGNC:33116] |
| Ensembl ID | ENSG00000188487 |
| Bio databases IDs | |
| Aliases | INSC spindle orientation adaptor protein, inscuteable spindle orientation adaptor protein |
| Synonyms | 3830422K02Rik, C730020D23, INSC spindle orientation adaptor protein, INSC, spindle orientation adaptor protein, RGD1311379 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human INSC often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Inscuteable LGN-binding domain
- protein binding activity, bridging
- protein domain specific binding
- protein binding
- LGN-binding domain (LBD) of protein Inscuteable (INSC) and similar proteins
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sporadic parathyroid adenoma
- parathyroid adenoma
role in cell
- expression in
- number
- metaphase/anaphase transition
- orientation in
- misorientation in
- orientation
- misorientation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell cortex
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human INSC gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- establishment of mitotic spindle orientation
- regulation of protein stability
- apical protein localization
- cell differentiation
- nervous system development
- regulation of asymmetric cell division
- asymmetric cell division
Cellular Component
Where in the cell the gene product is active
- cell cortex
- macromolecular complex
- apical cortex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- cytoskeletal adaptor activity
- protein binding, bridging