Vps37c Gene Summary [Mouse]
Predicted to enable calcium-dependent protein binding activity. Predicted to be involved in protein targeting to membrane; protein targeting to vacuole; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be located in several cellular components, including Golgi apparatus; late endosome membrane; and nucleoplasm. Predicted to be part of ESCRT I complex. Is expressed in glossopharyngeal ganglion; liver lobe; trigeminal ganglion; and vibrissa. Orthologous to human VPS37C (VPS37C subunit of ESCRT-I). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vps37c |
| Official Name | vacuolar protein sorting 37C [Source:MGI Symbol;Acc:MGI:2147661] |
| Ensembl ID | ENSMUSG00000048832 |
| Bio databases IDs | |
| Aliases | vacuolar protein sorting 37C |
| Synonyms | 5730409F24RIK, FLJ20847, RGD1309258, vacuolar protein sorting 37C, VPS37C subunit of ESCRT-I |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vps37c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- Modifier of rudimentary (Mod(r)) protein
- protein binding
Pathways
Biological processes and signaling networks where the Vps37c gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cilia
- Golgi Apparatus
- cytosol
- endosomal membrane
- nucleoplasm
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vps37c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- membrane fission
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- protein targeting to membrane
- protein targeting to vacuole
- macroautophagy
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- extracellular vesicular exosome
- ESCRT I complex
- endosome membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium-dependent protein binding