Prex2 Gene Summary [Mouse]
Predicted to enable GTPase activator activity; guanyl-nucleotide exchange factor activity; and protein serine/threonine kinase inhibitor activity. Acts upstream of or within adult locomotory behavior; dendrite morphogenesis; and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in plasma membrane. Is expressed in brain ventricular layer and gut. Human ortholog(s) of this gene implicated in Klatskin's tumor and cholangiocarcinoma. Orthologous to human PREX2 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prex2 |
| Official Name | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 [Source:MGI Symbol;Acc:MGI:1923385] |
| Ensembl ID | ENSMUSG00000048960 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 |
| Synonyms | 6230420N16RIK, C030045D06RIK, D430013K02, DEP.2, DEPDC2, FLJ12987, phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2, PPP1R129 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prex2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
- DEP
- Domain present in PSD-95, Dlg, and ZO-1/2
- RhoGEF
- guanyl-nucleotide exchange factor
- canonical PDZ domain
- PH domain
- GTPase activator
- Pleckstrin homology-like domain
- PDZ domain
- RhoGEF domain
Pathways
Biological processes and signaling networks where the Prex2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- metastasis
- insulin resistance
- lip cancer
- clear-cell ovarian carcinoma
- clear cell ovarian cancer
- melanoma cancer
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
role in cell
- activation in
- phosphorylation in
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prex2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein kinase B signaling cascade
- regulation of signaling
- G-protein coupled receptor signaling pathway
- regulation of small GTPase mediated signal transduction
- adult locomotory behavior
- positive regulation of GTPase activity
- dendrite morphogenesis
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTPase activator activity
- guanyl-nucleotide exchange factor activity