Prex2

Predicted to enable GTPase activator activity; guanyl-nucleotide exchange factor activity; and protein serine/threonine kinase inhibitor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and negative regulation of TOR signaling. Predicted to act upstream of or within adult locomotory behavior; dendrite morphogenesis; and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Klatskin's tumor and cholangiocarcinoma. Orthologous to human PREX2 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prex2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Prex2 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Prex2 gene, providing context for its role in the cell.