Slc17a5 Gene Summary [Mouse]
Enables D-glucuronate transmembrane transporter activity. Involved in neurotransmitter loading into synaptic vesicle. Acts upstream of or within response to bacterium. Located in cytoplasmic vesicle and plasma membrane. Is active in glutamatergic synapse; lysosomal membrane; and synaptic vesicle membrane. Is expressed in several structures, including gut; liver; metanephros; nervous system; and sensory organ epithelium. Used to study lysosomal storage disease and sialuria. Human ortholog(s) of this gene implicated in sialuria. Orthologous to human SLC17A5 (solute carrier family 17 member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc17a5 |
| Official Name | solute carrier family 17 (anion/sugar transporter), member 5 [Source:MGI Symbol;Acc:MGI:1924105] |
| Ensembl ID | ENSMUSG00000049624 |
| Bio databases IDs | |
| Aliases | solute carrier family 17 (anion/sugar transporter), member 5 |
| Synonyms | 4631416G20RIK, 4732491M05, AST, HP59, ISSD, Lysosomal Sialic Acid Transporter, NSD, SD, SIALIN, SIASD, SLD, solute carrier family 17 (anion/sugar transporter), member 5, solute carrier family 17 member 5, VEAT |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc17a5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphoglycerate transporter family protein
- dileucine internalization motif
- sugar porter
- benzoate transport
- transmembrane domain
- Major Facilitator Superfamily
- sialic acid transporter
- Na(+)-dependent inorganic phosphate cotransporter
- D-glucuronate transporter
- sialic acid permease
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infantile sialic acid storage disorder
- Salla disease
- hereditary disorder
- global developmental delay with intellectual disability
- melanoma
- melanoma cancer
- sialic acid storage disease
- cerebral hemorrhage
regulates
- sialic acids
- neuraminic acid
- nitrate
- 3-iodothyronamine
- anion
- ion
role in cell
- morphology
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic vesicle membrane
- glutaminergic synapse
- intracellular space
- cellular membrane
- lysosome
- cytosol
- lysosome membrane
- late endosomes
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc17a5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to bacterium
- ion transport
- sialic acid transport
- carbohydrate transmembrane transport
- anion transport
- D-glucuronate transport
- amino acid transport
Cellular Component
Where in the cell the gene product is active
- membrane
- cytosol
- synaptic vesicle membrane
- basolateral plasma membrane
- plasma membrane
- lysosomal membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- sialic acid transmembrane transporter activity
- D-glucuronate transmembrane transporter activity
- sugar:hydrogen symporter activity
- sialic acid:hydrogen symporter activity