Cyp8b1 Gene Summary [Mouse]
Predicted to enable sterol 12-alpha-hydroxylase activity. Involved in bile acid biosynthetic process and positive regulation of intestinal cholesterol absorption. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including liver; lung; skeletal muscle; spleen; and testis. Orthologous to human CYP8B1 (cytochrome P450 family 8 subfamily B member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyp8b1 |
| Official Name | cytochrome P450, family 8, subfamily b, polypeptide 1 [Source:MGI Symbol;Acc:MGI:1338044] |
| Ensembl ID | ENSMUSG00000050445 |
| Bio databases IDs | |
| Aliases | cytochrome P450, family 8, subfamily b, polypeptide 1 |
| Synonyms | CP8B, CYP12, CYP8B, CYPVIIIB1, cytochrome P450 family 8 subfamily B member 1, cytochrome P450, family 8, subfamily b, polypeptide 1, Sterol 12-α hydroxylase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cyp8b1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- 7α-hydroxycholest-4-en-3-one 12α-hydroxylase
- oxygen binding
- sterol 12-alpha-hydroxylase
- enzyme
Pathways
Biological processes and signaling networks where the Cyp8b1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- Alzheimer disease
- hepatitis B virus-related hepatocellular carcinoma
- cerebrotendinous xanthomatosis
- steatorrhea
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cyp8b1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of intestinal cholesterol absorption
- bile acid biosynthetic process
- sterol metabolic process
- response to nutrient levels
- response to cholesterol
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- oxygen binding
- sterol 12-alpha-hydroxylase activity
- iron ion binding
- 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase activity
- 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity
- heme binding